Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect
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چکیده
منابع مشابه
Anti-complement effects of lactoferrin-derived peptides.
Lactoferrin is an important biological molecule with many functions such as modulation of the inflammatory response, iron metabolism and antimicrobial defense. One effect of lactoferrin is the inhibition of the classical complement pathway. This study reports that antimicrobial peptides derived from the N-terminal region from both human and bovine lactoferrin, lactoferricin H and lactoferricin ...
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Several peptides sharing high sequence homology with lactoferricin B (Lf-cin B) were generated from bovine lactoferrin (Lf) with recombinant chymosin. Two peptides were copurified, one identical to Lf-cin B and another differing from Lf-cin B by the inclusion of a C-terminal alanine (lactoferricin). Two other peptides were copurified from chymosin-hydrolyzed Lf, one differing from Lf-cin B by t...
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Cardiovascular diseases (CVD) are a major health problem in the industrialized countries, representing the main cause of death in the world. It is estimated that 17 million people globally die of CVD every year and these diseases are responsible for more than half of all deaths in Europe [1]. Therefore, primary prevention is becoming an increasing part of public health strategies aimed at reduc...
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High blood pressure or hypertension is a major risk factor for a number of chronic diseases among human beings. A progressive rise in blood pressure can lead to haemorrhagic stroke, myocardial infarction, heart failure, chronic kidney disease, cognitive decline and premature death. The past decade has seen a constant increase in prevalence of hypertension among populations because of changes in...
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Angiotensin I-converting enzyme (ACE)-inhibitory peptides from the thermolysin digest of chicken muscle and the peptic digest of ovalbumin were isolated. However, some of them failed to show antihypertensive activity in spontaneously hypertensive rats (SHR). To clarify this discrepancy, ACE-inhibitory peptides from various sources were preincubated with ACE before measurement of ACE-inhibitory ...
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ژورنال
عنوان ژورنال: Journal of Agricultural and Food Chemistry
سال: 2013
ISSN: 0021-8561,1520-5118
DOI: 10.1021/jf404616f